NNMT Inhibitor
5-Amino-1MQ
Independently lab-verified NNMT inhibitor, HPLC & LC-MS tested.
Strength
₱3,000.00 PHP
100 units in stock · SKU AMINO1MQ-50
Independently lab-verified. HPLC & LC-MS tested. Ships nationwide across the Philippines.
Product information
Research summary
5-Amino-1MQ is a small-molecule inhibitor rather than a peptide — a quinolinium compound included in this catalogue as a companion to the metabolic and mitochondrial research compounds. It is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase. NNMT catalyses the methylation of nicotinamide to 1-methylnicotinamide, consuming S-adenosylmethionine in the process. That reaction sits at a branch point: nicotinamide diverted to methylation is nicotinamide unavailable for salvage back into NAD+. Published research therefore examines NNMT inhibition as a route to influencing cellular NAD+ availability and methyl donor balance simultaneously. NNMT is highly expressed in adipose tissue and its expression is reported to be elevated in obesity models, which is the basis for the in-vitro and preclinical work on adipocyte metabolism, lipogenesis and energy expenditure. Each lot is assayed by HPLC for purity and confirmed by mass spectrometry, with batch-linked data published for every release.
Handling & reconstitution
Supplied as a powder. As a quaternary ammonium salt it behaves differently from the peptides in this catalogue. It is water-soluble, and for most aqueous applications sterile water is a suitable solvent — an advantage over the lipophilic small molecules here, which need organic co-solvents. For cell culture work a concentrated stock in DMSO is also common where a low final solvent volume is wanted. Allow the container to reach room temperature before opening; the compound is hygroscopic and cold surfaces attract condensation. Reseal promptly after weighing or withdrawal.
Storage
Dry compound: -20 °C, tightly sealed and protected from moisture and light. Desiccated storage is worth maintaining — the salt draws atmospheric water, and a deliquesced powder is difficult to weigh accurately. Aqueous or DMSO stock: aliquot and store at -20 °C, protected from light. As a small molecule it is chemically more robust in solution than any peptide here and is not subject to proteolysis or aggregation; the practical limits are photodegradation and, for DMSO stocks, moisture accumulation across repeated openings.
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